DEPENDENCE OF HALOTHANE POTENCY ON pH

Dependence of halothane potency on pH.

The effect of halothane on the amplitude and conduction time of the evoked nerve action potential of a mammalian nerve preparation was determined in vitro. The action of 4 per cent v/v halothane on the action potential was measured at three different hydrogen ion concentrations in the Krebs perfusate, namely, pH 6.57, pH 7.40, pH 8.00. Halothane potency, assessed by the depression of the action...

Effect of pH and halothane on muscle and liver mitochondria.

MITCHELSON, K. R., AND F. J. R. HIRD. Effect of pH and halothane on muscle and liver mitochondria. Am. J. Physiol. 225(6) : 1393-l 398. 1973.-The separate and combined effects of hydrogen ions and of the anesthetic halothane on skeletal muscle mitochondria have been studied using pyruvate plus malate as the substrate. Below pH ‘6.5 and pH 6.0 there was a rapid fall in State 3 respiration and th...

Dependence of mitochondrial K+ flux on pH.

pH dependence of sphingosine aggregation.

Sphingosine and sphingosine 1-phosphate (S1P) are sphingolipid metabolites that act as signaling messengers to activate or inhibit multiple downstream targets to regulate cell growth, differentiation, and apoptosis. The amphiphilic nature of these compounds leads to aggregation above their critical micelle concentrations (CMCs), which may be important for understanding lysosomal glycosphingolip...

The Phase Transition of DMPG and its Dependence on pH